Navraj Pannu | Biophysical Structural Chemistry

Navraj Pannu, Ph.D.

Position:

Assistant Professor

Telephone number: +31 (0)71 527 4414
Fax number: +31 (0)71 527 4357
E-mail address: raj@chem.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden Institute of Chemistry, Biophysical Structural Chemistry
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber 0.3.07

Biography

Educational background

September 2001 - current: Universitair Docent/Assistant Professor (tenured), Biophysical Structural Chemistry Dept., Leiden University, The Netherlands
October 2000 - October 2006: Title A Research Fellow, Trinity College, University of Cambridge, UK
October 1998 - December 2001: Ph.D., Trinity College, University of Cambridge, UK
January 1998 - May 1998: Sessional Lecturer, Mathematical Sciences Dept., University of Alberta, Canada
September 1995 - December 1997: M.Sc. Applied Mathematics, University of Alberta, Canada
September 1991 - April 1995: B.Sc. Applied Mathematics (First Class Honors), University of Alberta, Canada

Awards/Grants

NWO Toptalent grant (180 000 Euros from 1 October 2008 to 1 October 2012).
(Co-authored the grant received by Elisabeth M. Meulenbroek.)
NWO Innovational Research “Vidi” grant (600 000 Euros from August 2005 to August 2011).
Cyttron: X-ray crystallography pro ject leader (250 000 Euros from September 2004 to September 2008).
NWO Innovational Research “Veni” grant (200 000 Euros from April 2003 to April 2006).
Wellcome Trust Prize Studentship from June 1998 to June 2001.
Natural Sciences and Engineering Research Council of Canada Postgraduate
Scholarship B from October 1998 to October 2000 and Postgraduate Scholarship A from September 1995 to September 1997.
Alberta Heritage Foundation for Medical Research Studentship from September 1995 to December 1997.

2012

Liu, Z., Galli, F., Waterreus, W.J., Meulenbroek, E., Koning, R. I, Lamers, G.E., Olsthoorn, R.C., Pannu, N., Oosterkamp, T.H., Koster, A.J., Dame, R.T., Abrahams, J.P. , Single-Walled Carbon Nanotubes as Scaffolds to Concentrate DNA for the Study of DNA-Protein Interactions, Chemphyschem : a European journal of chemical physics and physical chemistry. DOI

Meulenbroek, E.M., Thomassen, E.A.J., Pouvreau, L., Abrahams, J.P., Gruppen, H., Pannu, N.S. , Structure of a post-translationally processed heterodimeric double-headed Kunitz-type serine protease inhibitor from potato, Acta Crystallographica Section D-Biological Crystallography, vol. 68, pp. 794-799.

Meulenbroek, E.M., Pannu, N.S. , Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Cockayne syndrome protein A in complex with DNA damage-binding protein 1, Acta crystallographica. Section F, Structural biology and crystallization communications, vol. 68, no. Pt 1, pp. 45-8. DOI

Meulenbroek, E.M., Peron Cane, C., Jala, I, Iwai, S., Moolenaar, G.F., Goosen, N., Pannu, N.S. , UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions, Nucleic acids research. DOI

2011

Kuzmanic, A., Kruschel, D., van Gunsteren, W.F., Pannu, N.S., Zagrovic, B. , Dynamics May Significantly Influence the Estimation of Interatomic Distances in Biomolecular X-ray Structures, Journal of molecular biology, vol. 411, no. 1, pp. 286-97. DOI

Winn, M.D., Ballard, C.C., Cowtan, K.D., Dodson, E.J., Emsley, P., Evans, P.R., Keegan, R.M., Krissinel, E.B., Leslie, A.G.W., McCoy, A., McNicholas, S.J., Murshudov, G.N., Pannu, N.S., Potterton, E.A., Powell, H.R., Read, R.J., Vagin, A. , Overview of the CCP4 suite and current developments, Acta Crystallographica Section D-Biological Crystallography, vol. 67, pp. 235-242. DOI

Skubak, P., Pannu, N.S. , Reduction of density-modification bias by beta correction, Acta Crystallographica Section D-Biological Crystallography, vol. 67, pp. 345-354. DOI

Pannu, N.S., Waterreus, W.J., Skubak, P., Sikharulidze, I, Abrahams, J.P., de Graaff, R.A.G. , Recent advances in the CRANK software suite for experimental phasing, Acta Crystallographica Section D-Biological Crystallography, vol. 67, pp. 331-337. DOI

Murshudov, G.N., Skubak, P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Long, F., Vagin, A.A. , REFMAC5 for the refinement of macromolecular crystal structures, Acta Crystallographica Section D-Biological Crystallography, vol. 67, pp. 355-367. DOI

2010

Skubak, P., Waterreus, W.J., Pannu, N.S. , Multivariate phase combination improves automated crystallographic model building, Acta Crystallogr D Biol Crystallogr, vol. 66, no. Pt 7, pp. 783-8. DOI

2009

Skubak, P., Murshudov, G., Pannu, N.S. , A multivariate likelihood SIRAS function for phasing and model refinement, Acta Crystallographica Section D-Biological Crystallography, vol. 65, pp. 1051-1061. DOI

Meulenbroek, E.M., Paspaleva, K., Thomassen, E.A.J., Abrahams, J.P., Goosen, N., Pannu, N.S. , Involvement of a carboxylated lysine in UV damage endonuclease, Protein Science, vol. 18, no. 3, pp. 549-558. DOI

Pannu, N.S., Ravelli, R.B.G., Abrahams, P. , The Max-Inf2/Lorentz Center workshop on New algorithms in macromolecular crystallography and electron microscopy, Acta Crystallographica Section D-Biological Crystallography, vol. 65, pp. 623-624. DOI

de Geus, D.C., Thomassen, E.A.J., Hagedoorn, P.L, Pannu, N.S., van Duijn, E., Abrahams, J.P. , Crystal Structure of Chlorite Dismutase, a Detoxifying Enzyme Producing Molecular Oxygen, J. Mol. Biol. . DOI

2007

Paspaleva, K., Thomassen, E., Pannu, N.S., Lwai, S., Moolenaar, G.F., Goosen, N., Abrahams, J.P. , Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease, Structure, vol. 15, no. 10, pp. 1316-1324. DOI

Abrahams, J.P., Plaisier, J.R., Ness, S., Pannu, N.S. , Phase refinement through density modification, Macromolecular Crystallography: Conventional And High-throughput Methods: Oxford University Press. DOI

2005

Skubak, P., Ness, S., Pannu, N.S. , Extending the resolution and phase-quality limits in automated model building with iterative refinement, Acta Crystallographica Section D-Biological Crystallography, vol. 61, pp. 1626-1635. DOI

2004

Ness, S.R., de Graaff, R.A., Abrahams, J.P., Pannu, N.S. , CRANK: new methods for automated macromolecular crystal structure solution, Structure, vol. 12, no. 10, pp. 1753-61. DOI

van Roon, A.M.M., Pannu, N.S., de Vrind, J.P.M., van der Marel, G.A., van Boom, J.H., Hokke, C.H., Deelder, A.M., Abrahams, J.P. , Structure of an anti-Lewis X fab fragment in complex with its Lewis X antigen, Structure, vol. 12, no. 7, pp. 1227-1236. DOI

Pannu, N.S., Read, R.J. , The application of multivariate statistical techniques improves single-wavelength anomalous diffraction phasing, Acta Crystallographica Section D-Biological Crystallography, vol. 60, pp. 22-27. DOI

Skubak, P., Murshudov, G.N., Pannu, N.S. , Direct incorporation of experimental phase information in model refinement, Acta Crystallographica Section D-Biological Crystallography, vol. 60, pp. 2196-2201. DOI

van Roon, A.M.M., Bink, H.H.J., Plaisier, J.R., Pleij, C.W.A., Abrahams, J.P., Pannu, N.S. , Crystal structure of an empty capsid of turnip yellow mosaic virus, Journal of Molecular Biology, vol. 341, no. 5, pp. 1205-1214. DOI

2003

Pannu, N.S., McCoy, A.J., Read, R.J. , Application of the complex multivariate normal distribution to crystallographic methods with insights into multiple isomorphous replacement phasing, Acta Crystallographica Section D-Biological Crystallography, vol. 59, pp. 1801-1808. DOI

van Roon, A.M.M., Pannu, N.S., Hokke, C.H., Deelder, A.M., Abrahams, J.P. , Crystallization and preliminary X-ray analysis of an anti-LewisX Fab fragment with and without its LewisX antigen, Acta Crystallographica Section D-Biological Crystallography, vol. 59, pp. 1306-1309. DOI

Plaisier, J.R., Koning, R. I, Koerten, H.K., van Roon, A.M., Thomassen, E.A.J., Kuil, M.E., Hendrix, J., Broennimann, C., Pannu, N.S., Abrahams, J.P. , Area detectors in structural biology, Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment, vol. 509, no. 1-3, pp. 274-282. DOI

Navraj Pannu teaches or supervises the following courses:

Navraj currently supervises the following students:

Pavol Skubak

30/08/2011

Biophysical Structural Chemistry

Navraj Pannu, Ph.D.

Biography

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